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Right Ventricular Assist System Feedback Flow Control Parameter for a Rotary Blood Pump
Author(s) -
Yoshikawa Masaharu,
Nakata Kinichi,
aka Kenji,
Linneweber Joerg,
Kawahito Shinji,
Takano Tamaki,
ShulteEistrup Sebastian,
Maeda Tomohiro,
Glueck Julia,
Schima Heinrich,
Wolner Ernst,
Nosé Yukihiko
Publication year - 2000
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2000.06579.x
Subject(s) - hemodynamics , medicine , heart rate , cardiology , blood flow , ventricular assist device , anesthesia , artificial heart , cardiac output , treadmill , blood pressure , heart failure , biomedical engineering
At least 25–30% of patients with a permanent implantable left ventricular assist device (LVAD) experience right ventricular failure; therefore, an implantable biventricular assist system (BiVAS) with small centrifugal pumps is being developed. Many institutions are focusing and developing a control system for a left ventricular assist system (LVAS) with rotary blood pumps. These authors feel that the right ventricular assist system (RVAS) with rotary blood pumps should be developed simultaneously. A literature search indicated no recent reports on the effect of hemodynamics and exercise with this type of nonpulsatile implantable RVAS. In this study, a calf with an implantable right ventricular assist system (RVAS) was subjected to 30 min of exercise on a treadmill at 1.5 mph, resulting in excellent hemodynamics. The input voltage remained unchanged. Hemodynamic recordings were taken every 5 min throughout the testing period, and blood gas analysis was done every 10 min. Oxygen uptake (VO 2 ), oxygen delivery (DO 2 ), and oxygen extraction (O 2 ER) were calculated and analyzed. Two different pump flows were investigated: Group 1 low assist (<3.5 L/min) and Group 2 high assist (>3.5 L/min). In both groups, the RVAS flow rates were unchanged while the pulmonary artery (PA) flow increased during exercise; also, the heart rate and right atrial pressure (RAP) increased during exercise. There were no significant differences in the 2 groups. The PA flow correlates to the heart rate during exercise. In all of the tests, the VO 2 and DO 2 increased during exercise. Regarding VO 2 , no changes were observed during the different flow conditions; however, the DO 2 of Group 2 was higher than that of Group 1. Because the implantable RVAS did not have pump flow changes during the test conditions, it was necessary to incorporate a flow control system for the implantable RVAS. During exercise with an implantable RVAS rotary blood pump, incorporating the heart rate and VO 2 as feedback parameters is feasible for controlling the flow rate.