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Supplemental Systemic Oxygen Support Using an Intestinal Intraluminal Membrane Oxygenator
Author(s) -
Gross Brian D.,
Sacristán Emilio,
Peura Robert A.,
Shahnarian Albert,
Devereaux Daniel,
Wang HiaLong,
FiddianGreen Richard
Publication year - 2000
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2000.06563.x
Subject(s) - oxygenator , oxygenation , hypoxia (environmental) , medicine , membrane oxygenator , hemoglobin , ileum , cardiac output , anesthesia , oxygen , chemistry , cardiology , hemodynamics , extracorporeal membrane oxygenation , cardiopulmonary bypass , organic chemistry
An intraluminal membrane oxygenator (IMO) prototype was surgically inserted in the ileum and evaluated as a method of supporting systemic oxygenation in an acutely hypoxemic porcine model. Animals were assigned randomly to the test (n = 12) or the control (n = 8) groups, which underwent identical protocols with the exception of the O 2 flow in the IMO device, which was shut off in the control group. In each case, hypoxia was induced by a reduction in the inspired oxygen fraction (Fi o 2 ) to 0.14. A highly significant improvement (p < 0.005) in arterial and venous O 2 content and lower arteriovenous O 2 difference (p < 0.05), cardiac output, and hemoglobin (p < 0.005) were found in the test group during hypoxia. The results show that it is possible to meet a physiologically significant portion of the body's O 2 demands via the intestine during respiratory hypoxia and suggests that similar devices may be of significant potential value as a supplemental oxygenation device in cases of respiratory distress.