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Preparation and Characterization of Collagen‐Elastin Matrices From Blood Vessels Intended as Small Diameter Vascular Grafts
Author(s) -
Goissis Gilberto,
Suzigan Sueli,
Parreira Diderot Rodrigues,
Maniglia José Vitor,
Braile Domingo Marcolino,
Raymundo Selma
Publication year - 2000
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2000.06537.x
Subject(s) - elastin , matrix (chemical analysis) , extracellular matrix , chemistry , blood vessel , biomedical engineering , anatomy , pathology , biochemistry , biology , chromatography , medicine
This study describes the selective removal of cell and cell residues from small and large diameter blood vessels for the preparation of tubular collagen:elastin matrices intended for small diameter vascular prosthesis. The results showed that total or partially devitalized collagen:elastin matrices may be conveniently prepared without denaturation of the collagen:elastin matrix with a high degree of preservation of the proteins. The efficiency of cell removal and the extent collagen and elastic fiber preservation were dependent on the segment and the type of blood vessel under study, with arteries characterized by a higher susceptibility of cell removal and better preservation of the collagen‐elastin matrix.