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Combined Effects of Inhaled Nitric Oxide and Positive End‐Expiratory Pressure During Mechanical Ventilation in Acute Respiratory Distress Syndrome
Author(s) -
Okamoto Kazufumi,
Kukita Ichiro,
Hamaguchi Masamichi,
Motoyama Takeshi,
Muranaka Hiroyuki,
Harada Toshikazu
Publication year - 2000
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2000.06496-3.x
Subject(s) - ards , positive end expiratory pressure , oxygenation , medicine , mechanical ventilation , nitric oxide , anesthesia , acute respiratory distress , ventilation (architecture) , cardiology , lung , mechanical engineering , engineering
We studied the combined effects of inhaled nitric oxide (INO) and positive end expiratory pressure (PEEP) during mechanical ventilation in patients with acute respiratory distress syndrome (ARDS). Eleven patients received 0 and 4 parts per million of INO in random order for 30 min at PEEP levels of 0, 5, and 10 cm H 2 O. Respiratory and cardiovascular parameters were measured. The addition of INO and PEEP significantly improved arterial oxygenation (p < 0.005 and p < 0.0001, respectively). The combined effect of INO and PEEP on arterial oxygenation was remarkable during 10 cm H 2 O PEEP. There was synergistic effect on arterial oxygenation by combining INO and 10 cm H 2 O PEEP. The present study showed that the combination of INO and 10 cm H 2 O PEEP enhanced arterial oxygenation in patients with ARDS.