Premium
Natural Changes in Peritoneal Equilibration Test Results in Continuous Ambulatory Peritoneal Dialysis Patients: A Retrospective, Seven Year Cohort Survey
Author(s) -
Hung KuanYu,
Huang JenqWen,
Tsai TunJun,
Chen WanYu
Publication year - 2000
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2000.06478.x
Subject(s) - peritoneal equilibration test , medicine , peritoneal dialysis , continuous ambulatory peritoneal dialysis , ambulatory , retrospective cohort study , ultrafiltration (renal) , cohort , diabetes mellitus , urology , creatinine , endocrinology , surgery , chemistry , biochemistry
We conducted a retrospective, 7 year cohort survey to examine the natural changes in peritoneal equilibration test (PET) results in patients with long‐term uneventful continuous ambulatory peritoneal dialysis (CAPD). Thirty‐two (17 males, 15 females) patients on CAPD with two or more standard PETs performed more than 6 months apart, in the absence of peritoneal insult, were included. Changes and pattern of PET results were evaluated by the dialysate to plasma ratio of creatinine (D:P‐cre), the fourth h dialysate to instilled glucose ratio (D 4 :Do) and ultrafiltration volume (UF, ml). The subgroups included high (H), high‐average (HA), low‐average (LA), or low (L) transporters with the dividing ratios (D:P‐cre) of >0.81, >0.65 to 0.81, >0.5 to 0.65, and <0.5, respectively. The median D:P‐cre significantly decreased (p = 0.04), but neither the D 4 :Do nor the final median UF significantly decreased. The change in D:P‐cre was strongly and inversely correlated with the initial D:P‐cre value (r = −0.68; p < 0.05). A similar relationship was found between the change in the final D 4 :Do and the initial D 4 :Do (r = −0.752; p < 0.01) and between the change in the final UF and the initial UF (r = −0.875; p < 0.01). No correlation was found between the change in D:P‐cre and the age of the patient, the time interval between PETs, monthly dialysate glucose exposure, or underlying diabetes/non‐diabetes. The final peritoneal transport pattern was altered with 5 (15.6%) patients remaining in the extreme subgroups (H or L) and, by contrast, 84.4% (27/32) of the patients now in the averaged (HA or LA) groups (p < 0.01, χ 2 test). We demonstrated a natural “centralization” migration of PET results after long‐term uneventful CAPD, which may help to explain why patients with extreme PET characteristics, that is, H or L, continued to do well on CAPD.