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Validation of a Model for Flow‐Dependent Carbon Dioxide Exchange in Artificial Lungs
Author(s) -
Hout Mariah S.,
Hattler Brack G.,
Federspiel William J.
Publication year - 2000
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2000.06465.x
Subject(s) - artificial lung , volumetric flow rate , flow (mathematics) , carbon dioxide , chemistry , thermodynamics , range (aeronautics) , analytical chemistry (journal) , mechanics , biomedical engineering , materials science , chromatography , anesthesia , physics , medicine , composite material , organic chemistry
The exchange rate of CO 2 in artificial lungs depends on the sweep gas flow rate. Control of the amount of CO 2 removed by an artificial lung requires quantitative knowledge of the flow dependence. A simple model of the dependence of CO 2 exchange on sweep gas flow rate in artificial lungs has been previously presented (1). For a given partial pressure of CO 2 in the blood phase, sweep gas flow rate, and CO 2 exchange rate, the model indicates how close the CO 2 exchange rate is to the maximum level attainable by the artificial lung. The focus of this study was to validate the model experimentally by testing 2 commercial artificial lungs in an in vitro test loop. The CO 2 exchange rate for each artificial lung was measured over a range of sweep gas flow rates. Linear regression was used to fit the data to the model and estimate the maximum possible CO 2 exchange rate and the average water‐side P co 2 ( P co 2 w ). The difference between the measured and regressed values of P co 2 w was used as an indicator of the ability of the model to quantitatively predict the dependence of CO 2 exchange on gas flow rate. This difference was less than 5% for each experiment, indicating that the model can be used to guide control of CO 2 exchange rates in artificial lungs.