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Major Organ Function Under Mechanical Support: Comparative Studies of Pulsatile and Nonpulsatile Circulation
Author(s) -
Sezai Akira,
Shiono Motomi,
Orime Yukihiko,
Nakata Kinichi,
Hata Mitsumasa,
Iida Mitsuru,
Kashiwazaki Satoshi,
Kinoshita Junichi,
Nemoto Mitsuhiro,
Koujima Takashi,
Furuichi Motohiko,
Eda Kunihiro,
Hirose Hiroyuki,
Yoshino Takanori,
Saitoh Akira,
Taniguchi Yoshiki,
Sezai Yukiyasu
Publication year - 1999
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.1999.06318.x
Subject(s) - pulsatile flow , medicine , cardiology , cannula , ventricle , blood flow , renal circulation , hemodynamics , extracorporeal circulation , arterial blood , artery , aorta , anesthesia , renal blood flow , surgery
We examined a major organ function during 3 h biventricular assisted circulation after acute myocardial infarction model in the pig. In left ventricular circulation, the outflow cannula was placed in the ascending aorta and an inflow cannula through the mitral valve in the left ventricle. A pump (pulsatile group, Zeon Medical, Inc., Tokyo, Japan and nonpulsatile group, Nikkiso HPM‐15, Nikkiso, Inc., Tokyo, Japan) was connected to each cannula. In right ventricular circulation, the outflow cannula was placed in the pulmonary artery and an inflow canula in the right ventricle. The right ventricular circulation was supported by a nonpulsatile pump (Nikkiso HPM‐15). The items measured were the regional blood flows of the cortex and medulla in the kidney, white matter and gray matter in brain, and liver; renal arterial flow; carotid arterial flow; portal vein flow; common hepatic arterial flow; arterial ketone body ratio (AKBR); and lactate/pyrubic acid (L/P). In the pulsatile group, the renal cortical blood flow increased, and the medulla blood flow decreased. On the other hand, in the nonpulsatile group, both regional blood flows decreased. That means that in the pulsatile assisted group intrarenal redistribution improved rather than in the nonpulsatile assisted group. In addition the liver regional blood flow, AKBR, and L/P showed significant differences between the pulsatile and nonpulsatile groups. On the other hand, the white matter and gray matter regional blood flows and carotid arterial flow did not show significant differences between the groups. The results of our study indicated that pulsatile circulation produced superior circulation in the kidney and liver, and microcirculation on the cell level was superior as well in early treatment of acute heart failure.