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Heparin Coating Extends the Durability of Oxygenators Used for Cardiopulmonary Support
Author(s) -
Usui Akihiko,
Hiroura Manabu,
Kawamura Mitsuo
Publication year - 1999
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.1999.06208.x
Subject(s) - heparin , durability , oxygenator , medicine , cardiology , cardiopulmonary bypass , surgery , anesthesia , materials science , composite material
A comparative study was performed between a noncoated and heparin‐coated cardiopulmonary support (CPS) systems with the same design and structure (Terumo Corporation, Capiox‐SX series) to evaluate whether or not heparin coating extends oxygenator service life. Fifty patients underwent CPS from January 1993 until December 1997, and 54 oxygenators (Capiox‐SX series) were used. There were 35 noncoated oxygenators (Group NC) and 19 heparin‐coated ones (Group HC). Significant predictors for the durability of oxygenators were evaluated by a nonparametric survival analysis and a proportional hazards regression analysis. Thirteen of 35 Capiox‐SX and only 2 of 19 Capiox SX‐HP revealed gas transfer failure and had to be exchanged. The average life span of the Capiox‐SX and Capiox‐SX‐HP were calculated to be 78.6 ± 16.8 and 168 ± 15.4 h, respectively. Group HP showed significantly longer durability than Group NC (p = 0.0017), although there were differences of perfusion index and platelet counts between the 2 groups. Heparin coating of the CPS system remained one of the 2 significant predictors (hazards ratio 8.871, p = 0.0449) to determine the durability of oxygenators by increasing stepwise multivariate proportional hazards regression analysis, along with anemia with less than 8 g/dl hemoglobin (hazards ratio 9.438, p = 0.0173). Heparin coating of the CPS system assures improved durability because heparin‐coated oxygenators have a longer service life than noncoated ones.