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Effect of Ultrafiltration During Cardiopulmonary Bypass for Pediatric Cardiac Surgery
Author(s) -
Watanabe Takashi,
Sakai Yoshimasa,
Mayumi Toshihiko,
Shimomura Tsuyoshi,
Song MinHo,
Tajima Kazuyoshi,
Suenaga Yoshito,
Kawaradani Yoshitaka,
Saito Yasutaka,
Yamada Teiji
Publication year - 1998
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.1998.06192.x
Subject(s) - cardiopulmonary bypass , ultrafiltration (renal) , medicine , cardiac surgery , cardiology , intensive care medicine , chemistry , chromatography
The effect of ultrafiltration during cardiopulmonary bypass (CPB) was evaluated for correcting ventricular septal defects with associated pulmonary hypertension in patients less than 18 months old. Interleukin (IL)‐6 and IL‐8 concentrations in the blood, ultrafiltrate, and urine were measured. The blood IL‐6 concentration increased to 128.4 ± 20.2 pg/ml by the end of surgery, which is lower than the concentration seen in adult patients (273.1 ± 48.2 pg/ml, p < 0.02). The blood IL‐8 concentration was not significantly different than that of adults. The total amounts of excreted IL‐6 in the ultrafiltrate and urine during CPB were 11.5 ± 0.32 pg/kg and 0.32 ± 0.07 pg/kg, respectively (p < 0.05). The total amounts of excreted IL‐8 in the ultrafiltrate and urine were 4.64 ± 0.69 pg/kg and 1.92 ± 0.56 pg/kg, respectively (p < 0.05). No differences were seen in these values for excretion between children and adults. We conclude that ultrafiltration during CPB in pediatric patients is more effective in removing proinflammatory cytokines than in adults and more effective than renal filtration alone.