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A Continuous and Pulsatile Flow Circulation System for Evaluation of Cardiovascular Devices
Author(s) -
Vermette Patrick,
Thibault Jules,
Laroche Gaétan
Publication year - 1998
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.1998.06103.x
Subject(s) - pulsatile flow , flow (mathematics) , centrifugal pump , mechanics , peristaltic pump , materials science , positive displacement meter , biomedical engineering , amplitude , cylinder , backflow , circulation (fluid dynamics) , impeller , physics , cardiology , mechanical engineering , engineering , optics , medicine , thermodynamics , inlet
The design of a nonpulsatile and pulsatile system using a centrifugal pump is presented. To induce a pulsatile flow with a centrifugal pump, an independent pneumatically driven unit provided flow patterns over a wide range of frequencies and amplitudes. The pulsatile flow was generated by the axial displacement of a cylinder that periodically compressed the flexible conduit that is connected to the pump. The system can accommodate flow rates up to 6,000 ml/min and transmural pressures up to 500 mm Hg and is capable of maintaining the pressure at a constant value. This circuit produced reproducible pressure waves having a frequency up to 4 Hz. The periodicity of the transmural pressure between 80 and 180 mm Hg was similar to the pressure wave propagation observed in peripheral circulation. Capable of adequately reproducing continuous and pulsatile flow, the apparatus is therefore versatile to allow in vitro evaluation of cardiovascular devices.