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Endotoxin Removal Column Containing Polymyxin B Immobilized Fiber Is Useful for the Treatment of the Patient with Vibrio Vulnificus
Author(s) -
Sato Toshihide,
Tadakuma Natsuko,
Ikezaki Nobuhiko,
Hashiguchi Akira,
Masuda Kazuyuki
Publication year - 1998
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.1998.06085.x
Subject(s) - hemoperfusion , polymyxin b , polymyxin , vibrio vulnificus , fulminant , septic shock , microbiology and biotechnology , antibiotics , debridement (dental) , sepsis , medicine , bacteria , surgery , biology , hemodialysis , genetics
A case of primary septicemia due to Vibrio vulnificus infection is reported. The patient was successfully treated with appropriate antibiotic therapy, drainage, and debridement of the necrotic tissues and direct hemoperfusion (DHP) using polymyxin B immobilized fiber (PMX‐F). The effectiveness of DHP using PMX‐F, which removes endotoxin in the circulating blood for the treatment of septic shock and multiple organ dysfunction occurring due to this fulminant infectious disease, is discussed. Vibrio vulnificus infection causes fulminant and frequently fatal septicemia. The fatality rate for Vibrio vulnificus septicemia is very high ( 1, 2). Vibrio vulnificus is generally only pathogenic in immunocompromised hosts, and its pathogenicity is particularly related to liver diseases. Circulating endotoxin is considered to be seriously pathogenic in patients with Vibrio vulnificus infections. Direct hemoperfusion (DHP) using Polymyxin B immobilized fiber (PMX‐F) is a new treatment for endotoxemia which eliminates endotoxin from the blood circulation (3). We report a case of primary endotoxemia due to Vibrio vulnificus infection successfully treated by a combination of aggressive intensive care and DHP using PMX‐F.