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Serum Amyloid A and P Protein Levels are Lowered by Dextran Sulfate Cellulose Low‐Density Lipoprotein Apheresis
Author(s) -
Yoshidome Hiroaki,
Kuriyama Masaru,
Fujiyama Jiro,
Osame Mitsuhiro
Publication year - 1998
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.1998.05065.x
Subject(s) - apheresis , cellulose , ldl apheresis , dextran , chemistry , lipoprotein , low density lipoprotein , amyloid (mycology) , sulfate , medicine , biochemistry , cholesterol , organic chemistry , inorganic chemistry , platelet
The present study describes the short‐term effect of dextran sulfate cellulose (DSC) low‐density lipoprotein (LDL) apheresis using a plasma separator equipped with a polysulfone (PS) membrane filter (PS/DSC‐LDL apheresis) on the serum amyloid A (SAA) and P (SAP) protein levels during treatment in a patient with familial hypercholesterolemia (type IIa, heterozygote). PS/DSC‐LDL apheresis markedly lowered both the SAA (reduction percentage, 84.1 ± 8.2%) and SAP (91.4 ± 5%) levels, which returned to their respective initial levels within 4 days. Experimentally, the levels of both proteins also decreased on passage through the DSC minicolumn without a PS membrane, indicating that the DSC resin had an affinity to both proteins. These results suggest that PS/DSC‐LDL apheresis may be advantageous for amyloid protein accumulating disorders, including amyloidosis and atherosclerosis.