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Antigliadin Antibodies Associated with Chronic Mucocutaneous Candidiasis
Author(s) -
Garcia Yolanda Hidalgo,
Díez Santiago Gómez,
Aizpún Lourdes Tricas,
Oliva Narciso Pérez
Publication year - 2002
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1046/j.1525-1470.2002.00117.x
Subject(s) - medicine , chronic mucocutaneous candidiasis , mucocutaneous zone , immunology , candida albicans , fluconazole , antibody , mucous membrane , disease , dermatology , antifungal , microbiology and biotechnology , biology
Chronic mucocutaneous candidiasis (CMC) is a primary immunodeficiency disease clinically characterized by Candida infection of the skin, mucous membranes, or nails that is refractory to traditional treatment. We present a typical case of a 13‐year‐old boy with an onset of illness at 1 month of age in the form of oral thrush. At age 2–3 years the patient began to have external otitis caused by Candida albicans and recurrent upper respiratory tract infections. Analytical studies detected iron deficiency and circulating antigliadin antibodies. Immunologic findings excluded other possible immunodeficiencies. Significant clinical improvement was produced by therapy with orally administered fluconazole. The significance of antigliadin antibodies is discussed.