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Pityriasis Lichenoides in a Girl with the Granulomatous Form of Common Variable Immunodeficiency
Author(s) -
Pasic Srdjan,
Pavlovic Milos,
Vojvodic Danilo,
Abinun Mario
Publication year - 2002
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1046/j.1525-1470.2002.00012.x
Subject(s) - common variable immunodeficiency , medicine , prednisone , clobetasol propionate , dermatology , granulomatous disease , chronic granulomatous disease , pityriasis rosea , immunology , immunodeficiency , pathology , disease , immune system , antibody , psoriasis
Pityriasis lichenoides (PL) is a cutaneous disease of unknown origin. In our 8‐year‐old female patient with the granulomatous form of common variable immunodeficiency (CVID), PL occurred together with massive splenomegaly and intra‐abdominal lymphadenopathy. Prednisone was efficient for treatment of her splenomegaly and autoimmune cytopenias. However, PL was resistant to both topical and systemic steroid treatment. Healing of PL was achieved with the use of a superpotent topical steroid, clobetasol propionate. A defect of T‐cell function in CVID may contribute to development of PL. In the granulomatous form of CVID, sarcoidlike granulomas are the most commonly reported cutaneous lesions. PL has not been previously reported.