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Waxy Keratoses of Childhood in a Segmental Distribution
Author(s) -
Mehrabi Don,
Thomas Jean E.,
Angelica Selim M.,
Prose Neil S.
Publication year - 2001
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1046/j.1525-1470.2001.01968.x
Subject(s) - genodermatosis , loss of heterozygosity , medicine , trunk , dermatology , pathology , genetics , biology , allele , gene , ecology
Waxy keratoses of childhood is a rare genodermatosis previously noted in both familial and isolated presentations. Three previous cases have been described in which the lesions appeared over the trunk and extremities. We report a case in which the waxy keratoses of childhood lesions appeared in a segmental distribution along a single lower extremity, differing from the more extensive patterns reported previously. We suggest a possible postzygotic mutation hypothesis for this unique segmental distribution, addressing both the possibility of a genomic mosaicism and loss of heterozygosity.