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Low Dose Cyclosporin A Treatment in Generalized Pustular Psoriasis
Author(s) -
Kiliç S. Şebnem,
Hacimustafaoğlu Mustafa,
Çelebi Solmaz,
Karadeniz Aynur,
Ildirim Ibrahim
Publication year - 2001
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1046/j.1525-1470.2001.018003246.x
Subject(s) - medicine , psoriasis , dermatology , generalized pustular psoriasis , pustular psoriasis , scalp , parakeratosis , trunk , biopsy , pathology , ecology , biology
Generalized pustular psoriasis is a rare form of psoriasis, seldom seen in children. Three patients with generalized pustular psoriasis are presented, two of whom were a sister and brother and whose grandfather also had pustular psoriasis. Lesions consisted of pustular, erythematous, scaly, follicular papules located on the trunk, scalp, and extremities. The pustules in some areas coalesced to form lakes. Histologic examination of several biopsy specimens revealed the changes of pustular psoriasis, which were parakeratosis, elongation of the rete ridges, and deep spongioform pustules and Munro abscesses. All patients were treated with cyclosporin A for periods of 2–12 months. The doses ranged from 1 to 2 mg/kg/day. Clearance of psoriatic lesions occurred after 2–4 weeks of therapy.