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Progeria Infantum (Hutchinson–Gilford Syndrome) Associated with Scleroderma‐Like Lesions and Acro‐Osteolysis: A Case Report and Brief Review of the Literature
Author(s) -
Jansen Thomas,
Romiti Ricardo
Publication year - 2000
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1046/j.1525-1470.2000.01775.x
Subject(s) - progeria , medicine , premature aging , scalp , pathology , phalanx , scleroderma (fungus) , osteolysis , stridor , dermatology , anatomy , surgery , physiology , biochemistry , inoculation , gene , airway , chemistry
Progeria infantum (Hutchinson–Gilford syndrome) is a very rare syndrome of premature aging characterized by growth retardation and specific, progressive, premature senescent changes of the skin and other tissues. We report a 1.5‐year‐old girl with loss of scalp hair, eyebrows, and lashes, prominent scalp veins, micrognathia, abnormal ears, loss of subcutaneous tissue, and scleroderma‐like areas over the trunk. Radiographic studies revealed coxa valga and acro‐osteolysis of the terminal phalanges. The clinical and radiologic features corresponded well with progeria infantum.