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Onychomycosis in Children: Treatment with Bifonazole‐Urea
Author(s) -
Bonifaz Alexandro,
Ibarra Guadalupe
Publication year - 2000
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1046/j.1525-1470.2000.01761.x
Subject(s) - bifonazole , medicine , dermatology , adverse effect , urea , trichophyton rubrum , surgery , antifungal , chemistry , organic chemistry
We assessed the safety and efficacy of a two‐phase topical treatment with bifonazole‐urea ointment in children with onychomycosis. Twenty‐five children younger than 16 years old with proved onychomycosis were included in the study. Bifonazole‐urea ointment was administered under occlusion until the nontraumatic removal of the nail was achieved. Bifonazole cream was then applied for 4 weeks and a follow‐up visit 4 weeks after cessation of medication was scheduled. During the study, periodic clinical and mycologic evaluations were carried out. Of the 25 patients included, 17 were cured (68%), 6 improved, and 2 failed treatment. The main etiologic agent isolated was Trichophyton rubrum (92%). Two patients had minor side effects, both during the occlusive phase, one each with mild pain and a probable dermatitis from the adhesive strips. Treatment was not discontinued in both of these cases. We concluded that a two‐phase treatment with bifonazole‐urea is effective and safe, and represents a new therapeutic choice for onychomycosis in children.