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Transient Beneficial Effect of GH Replacement Therapy and Topical GH Application on Skin Ulcers in a Boy with Prolidase Deficiency
Author(s) -
Monafo Virginia,
Marseglia Gian Luigi,
Maghnie Mohamad,
Dyne Katherine M.,
Cetta Giuseppe
Publication year - 2000
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1046/j.1525-1470.2000.01760.x
Subject(s) - medicine , connective tissue , short stature , hormone replacement therapy (female to male) , growth hormone , dermatology , surgery , hormone , pathology , testosterone (patch)
A diagnostic examination for short stature in a boy with chronic ulcers of the feet due to prolidase deficiency, a rare disorder associated with intractable ulcers of the skin, led to the diagnosis of growth hormone (GH) deficiency. Replacement treatment with r‐hGH associated with the topical application of a GH‐containing ointment when the boy was 13 years old resulted in complete but transitory healing of the ulcers, which can probably be attributed to the growth‐promoting effects of GH on dermal connective tissue.