Premium
Acral Erythema in Children Receiving High‐Dose Methotrexate
Author(s) -
Millot Frédéric,
Auriol Francois,
Brecheteau Pierre,
Guilhot Francois
Publication year - 1999
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1046/j.1525-1470.1999.00105.x
Subject(s) - medicine , erythema , methotrexate , desquamation , lymphoblastic leukemia , chemotherapy , dermatology , surgery , leukemia
Scant information is available concerning the occurrence and evolution of chemotherapy‐induced acral erythema in children receiving intravenous high‐dose methotrexate (MTX). Among 50 children with acute lymphoblastic leukemia or lymphoblastic lymphoma receiving a total of 203 courses of high‐dose MTX (3–8 g/m 2 ), 3 cases of acral erythema were observed. Painful erythema of finger and toe pads was noted in three children 3 days to 2 weeks after MTX infusion. The lesions resolved completely after blister formation and desquamation. These patients subsequently received high‐dose MTX therapy without cutaneous problems. The present work points out that the chemotherapeutic schedule need not be modified in selected patients who develop acral erythema following high‐dose MTX infusion.