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Kasabach–Merritt Syndrome: Identification of Platelet Trapping in a Tufted Angioma by Immunohistochemistry Technique Using Monoclonal Antibody to CD61
Author(s) -
Seo Seon kyo,
Suh Jin chun,
Na Gun yeon,
Kim Ik su,
Sohn Kyung rak
Publication year - 1999
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1046/j.1525-1470.1999.00103.x
Subject(s) - medicine , immunohistochemistry , platelet , pathology , angioma , monoclonal antibody , lumen (anatomy) , antibody , vascular disease , immunology
Kasabach–Merritt syndrome (KMS) consists of large and rapidly growing vascular tumors associated with thrombocytopenia, generalized petechiae, and bleeding. The cause of the thrombocytopenia is thought to be related to the trapping of platelets by the abnormal endothelium of the tumor. We report an infant with KMS that developed in association with a large tufted angioma. In this case we directly demonstrated platelet trapping in the vascular lumen of the tumor by an immunohistochemical technique using a monoclonal antibody against CD61, a marker of platelets and megakaryocytes.