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From phenotype to genotype
Author(s) -
Streelman J. Todd,
Kocher Thomas D.
Publication year - 2000
Publication title -
evolution and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.651
H-Index - 78
eISSN - 1525-142X
pISSN - 1520-541X
DOI - 10.1046/j.1525-142x.2000.00056.x
Subject(s) - biology , decipher , phenotype , genomics , evolutionary biology , genotype , computational biology , transcriptome , genotype phenotype distinction , genetics , genome , gene , gene expression
SUMMARY Advances in the field of genomics have made it possible to decipher the genetic and transcriptional changes that underlie differences among organisms. Here we discuss the merits and drawbacks of these strategies as they relate to evolutionary biology. We suggest that the molecular basis of natural variation can best be interpreted via the intersection of genomic and transcriptome approaches. We outline how this might be accomplished in practice and assemble the components of a method to comprehend the evolutionary interplay between genotype and phenotype.