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Significance of Distribution Volume in Dialysis Quantification
Author(s) -
Sternby Jan
Publication year - 2001
Publication title -
seminars in dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 78
eISSN - 1525-139X
pISSN - 0894-0959
DOI - 10.1046/j.1525-139x.2001.00069.x
Subject(s) - medicine , dialysis , urea , volume (thermodynamics) , kt/v , dialysis adequacy , volume of distribution , hemodialysis , urology , intensive care medicine , thermodynamics , pharmacokinetics , biochemistry , chemistry , physics
ABSTRACT The urea distribution volume is in several ways an important parameter in the treatment of end‐stage renal disease (ESRD) patients. It has a major impact on the relative dose of dialysis treatment as measured by Kt / V . It is also important in the assessment of fluid status, which has a direct influence on blood pressure. Nevertheless, urea distribution volume is usually not measured on a regular basis, probably because it has been perceived as a relatively complicated measurement. With the arrival of on‐line monitors for dialysate urea this situation has improved radically. In this article a number of volume determination methods are discussed, including some new methods based on on‐line dialysate urea monitoring, which are shown to perform well in comparison to reference methods.