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Modalities for the Removal of β 2 ‐Microglobulin from Blood
Author(s) -
Ameer Guillermo A.
Publication year - 2001
Publication title -
seminars in dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 78
eISSN - 1525-139X
pISSN - 0894-0959
DOI - 10.1046/j.1525-139x.2001.00027.x
Subject(s) - medicine , beta 2 microglobulin , immunoadsorption , modalities , beta (programming language) , dialysis , amyloidosis , intensive care medicine , urology , surgery , immunology , computer science , social science , sociology , antibody , programming language
The long‐term accumulation of β 2 ‐microglobulin (β 2 M) in patients with kidney failure results in a debilitating condition referred to as dialysis‐related amyloidosis (DRA). There have been few methods specifically designed to remove the large quantities of β 2 M that are produced by the body. This article briefly reviews current modalities and concepts for the removal of β 2 M from blood. The various approaches are classified according to the mechanism of β 2 M clearance. The potential application of immunoadsorption, a biologically specific approach to remove macromolecules, in the treatment and understanding of DRA is discussed.