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Potential role of anaerobic cocci in impaired human wound healing
Author(s) -
Wall Ivan B.,
Davies Charlotte E.,
Hill Katja E.,
Wilson Melanie J.,
Stephens Phil,
Harding Keith G.,
Thomas David W.
Publication year - 2002
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1046/j.1524-475x.2002.t01-1-10602.x
Subject(s) - wound healing , anaerobic exercise , gram positive cocci , inflammation , anaerobic bacteria , microbiology and biotechnology , in vivo , biology , medicine , bacteria , immunology , physiology , staphylococcus aureus , genetics
Although more than 80% of infected and 70% of noninfected leg ulcers have been shown to harbor anaerobic organisms, their role in mediating impaired wound healing in the skin is frequently overlooked. There is now increasing evidence that the gram‐positive anaerobic cocci play a role (both directly and indirectly) in mediating impaired wound healing in vivo. This article discusses the mechanisms by which these microorganisms may interfere with the inflammation, repair, and remodeling phases of the wound healing process. (WOUND REP REG 2002;10:–353)