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Neonatal rat cartilage has the capacity for tissue regeneration
Author(s) -
WAGNER WOLFGANG,
REICHL JOACHIM,
WEHRMANN MANFRED,
ZENNER HANSPETER
Publication year - 2001
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1046/j.1524-475x.2001.00531.x
Subject(s) - regeneration (biology) , cartilage , in vivo , wound healing , microbiology and biotechnology , immunohistochemistry , pathology , transplantation , embryonic stem cell , regenerative medicine , biology , medicine , anatomy , stem cell , immunology , surgery , biochemistry , gene
One of the most relevant issues in future medicine is tissue regeneration. Transplantation medicine alone cannot solve the problem of incurable conditions of vital organs. One approach to this might be the replication of the spontaneous regeneration that is found in embryonic/neonatal tissue. In this study, a tissue model for basic investigation of regeneration mechanisms in vivo was established. We demonstrated by histology and immunohistochemical staining for types I and II collagen that neonatal rat cartilage unlike adult cartilage has the capacity for rapid scarfree regeneration after full‐thickness incision. The underlying mechanism was identified in the preserved proliferative capacity of neonatal chondrocytes. This in vivo model should prove useful in further studies of the role of cellular (e.g., GA cell cycle regulators) and extracellular (e.g., cytokines) factors in tissue regeneration and wound healing.