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Transforming growth factor‐β: crossroad of glucocorticoid and bleomycin regulation of collagen synthesis in lung fibroblasts
Author(s) -
Shukla Arti,
Meisler Natalie,
Cutroneo Kenneth R
Publication year - 1999
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1046/j.1524-475x.1999.00133.x
Subject(s) - bleomycin , transforming growth factor , extracellular matrix , growth factor , fibrosis , activator (genetics) , microbiology and biotechnology , pulmonary fibrosis , wound healing , chemistry , transforming growth factor beta , cancer research , biology , medicine , immunology , biochemistry , receptor , chemotherapy
Fibrosis is a consequence of injury which is characterized by accumulation of excess collagen and other extracellular matrix components, resulting in the destruction of normal tissue architecture and function. Transforming growth factor‐β, a potent wound healing agent, has also been shown to be an agent that can produce fibrosis because it is a potent stimulator of collagen synthesis. Both glucocorticoids and bleomycin have recently been shown to affect collagen synthesis in opposite directions, by utilizing a common pathway of involving transforming growth factor‐β activator protein binding to the transforming growth factor‐β element. This article presents a mechanistic overview of collagen synthesis regulation by glucocorticoids and bleomycin through the transforming growth factor‐β pathway.