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Chemokine and inflammatory cytokine changes during chronic wound healing
Author(s) -
Fivenson David P.,
Faria Duyen T.,
Nickoloff Brian J.,
Poverini Peter J.,
Kunkel Steven,
Burdick Marie,
Strieter Robert M.
Publication year - 1997
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1046/j.1524-475x.1997.50405.x
Subject(s) - wound healing , chemokine , angiogenesis , medicine , inflammation , cxc chemokine receptors , cytokine , immunology , chemokine receptor
Wound healing is a complex process resulting from an interplay of processes including coagulation, inflammation, angiogenesis, and epithelialization. The chemokine family has been shown to contain members that are potent regulators of many of these pathways. Because we have previously shown that chemokines “pool” in biologic wound dressings, we studied the levels of CXC and CC chemokines, along with key inflammatory mediators, serially from a group of patients undergoing therapy for chronic venous leg ulcers. After 8 weeks, all patients had marked clinical healing of their ulcers (median 63.3% reduction in size) with two of 10 completely healed. Wound fluids extracted from dressings showed high levels of platelet factor‐4 and interferon‐γ‐inducible protein, with a trend toward increases in the ratio of the sums of the angiogenic versus angiostatic CXC chemokines ( p = 0.082) in the tissues collected from the center of the ulcers during wound closure. Neutrophil‐activating peptide‐2 and interleukin‐8 accounted for the most changes in wound fluid angiogenic chemokines, with significant differences both as compared with baseline levels and with patients' plasma level noted at various time points between weeks 0 and 8. The level of angiostatic (cont.)