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Ketanserin accelerates wound epithelialization and neovascularization
Author(s) -
Kim Michael,
Tuncay Üstüner E.,
Schuschke Dale,
Morsing Anni,
Kjolseth Dorthe,
Fingar Victor,
Wieman Jeffrey,
Kamler Markus,
Tobin Gordon R.,
Bond Sheldon,
Barker John H.
Publication year - 1995
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1046/j.1524-475x.1995.30416.x
Subject(s) - ketanserin , medicine , hairless , wound healing , neovascularization , dorsum , vasodilation , arteriole , serotonin , surgery , microcirculation , receptor , anatomy , angiogenesis , chemistry , 5 ht receptor , biochemistry
We investigated the acute effects of topical ketanserin, a 5‐HT 2 (serotonin) receptor blocker, on wound epithelialization and vascularization with the use of the hairless mouse ear model. Varying concentrations of Ketanserin (0%, 0.2%, 2.0%, 20% weight/volume) were administered to standardized full‐thickness skin wounds on the dorsum of the hairless mouse ear immediately after surgery and daily thereafter. With the use of video microscopy and computer‐assisted planimetry, vascularization and epithelialization were traced every third day until the wounds were fully healed. Arteriole diameters at selected sites near the skin wound were measured before wound creation and after wounding. It was concluded that topically administered ketanserin significantly accelerates both the vascular ( p < 0.001 at 2% and 20% concentrations) and epithelial ( p < 0.001 at 20% concentration) rates of wound healing in full‐thickness nonpathologic skin wounds. Vasodilation of terminal arterioles was not a major response to Ketanserin. Faster epithelialization was possibly due to direct effect of ketanserin on epithelial cells.