Premium
Fibroblast heterogeneity in the healing wound
Author(s) -
Sempowski Gregory D.,
Borrello Melinda A.,
Blieden Timothy M.,
Barth Richard K.,
Phipps Richard P.
Publication year - 1995
Publication title -
wound repair and regeneration
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.847
H-Index - 109
eISSN - 1524-475X
pISSN - 1067-1927
DOI - 10.1046/j.1524-475x.1995.30204.x
Subject(s) - fibroblast , wound healing , extracellular matrix , regeneration (biology) , microbiology and biotechnology , tissue repair , pathogenesis , biology , cell type , myofibroblast , cell , immunology , cancer research , pathology , medicine , fibrosis , cell culture , genetics
Although fibroblasts are traditionally described as static cells providing framework and support for tissues, there is an accumulating body of evidence showing that fibroblasts are a dynamic cell type which exist in functionally and morphologically heterogeneous subpopulations. Fibroblast subsets have been shown to play a critical role in the production and regulation of extracellular matrix components, in wound repair and regeneration, and have been implicated in the pathogenesis of fibrotic conditions. We have reviewed the evidence supporting heterogeneity of fibroblasts from pulmonary, periodontal, and dermal tissues. In addition, we will explore the role fibroblast subpopulations may play in the complex process of wound repair and regeneration.