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Lansoprazole Quadruple Therapy Is Effective in Curing Helicobacter pylori Infection
Author(s) -
Korman Melvyn G.,
Bolin Terry D.,
Nicholson Fiona B.,
Engelman Jeffrey L.
Publication year - 1998
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1046/j.1523-5378.1998.08051.x
Subject(s) - lansoprazole , medicine , omeprazole , helicobacter pylori , gastritis , gastroenterology , metronidazole , proton pump inhibitor , peptic , population , urea breath test , regimen , peptic ulcer , helicobacter pylori infection , antibiotics , microbiology and biotechnology , environmental health , biology
Background. Quadruple therapy using omeprazole combined with classic bismuth triple therapy has been advocated as optimal therapy for the cure of Helicobacter pylori (H. pylori) infection. We investigated the efficacy of substituting lansoprazole for omeprazole in proton pump quadruple therapy. Materials and Methods. In a prospective open study, 219 consecutive patients, with either peptic ulcer disease or biopsy‐proven H. pylori ‐associated gastritis, received seven days of lansoprazole, bismuth, tetracycline and metronidazole after three days of lansoprazole pretreatment. Cure of infection was judged by 14 C urea breath test at six weeks after completion of therapy. Results. On an intention to treat basis, 198 of the 219 patients (90%) were confirmed to be cured of H. pylori infection. Compliance was excellent and minimal side effects reported. Conclusion. Lansoprazole‐based quadruple therapy achieves a very high cure rate in an unselected population of either peptic ulcer patients or those with H. pylori ‐associated gastritis. Recommended regimens should achieve at least 90% cure of infection. Lansoprazole quadruple therapy is effective and compares favorably with other H. pylori treatment regimens.