Premium
Cure of H. pylori Infection Using a 7‐Day Triple Therapy Combining Pantoprazole with Two Antibiotics
Author(s) -
Adamek Romuald J.,
Pfaffenbach Boris,
Szymanski Christian
Publication year - 1998
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1046/j.1523-5378.1998.08044.x
Subject(s) - pantoprazole , metronidazole , medicine , rapid urease test , gastroenterology , helicobacter pylori , amoxicillin , gastritis , adverse effect , antibiotics , placebo , omeprazole , microbiology and biotechnology , pathology , alternative medicine , biology
Background. Acid pump inhibitors combined with antimicrobials cure gastritis and peptic ulcer disease but a standard therapy has not yet been established. We therefore investigated a triple therapy with pantoprazole. Methods. The aim of this open‐label monocenter trial, involving 30 intention‐to‐treat patients with peptic ulcer disease or functional dyspepsia, was to assess the H. pylori cure rate after a 7‐day triple therapy with pantoprazole (40 mg bid) plus metronidazole (500 mg bid) and amoxicillin (1 g bid). The H. pylori status was assessed by rapid urease test, histological examination and culture at the initial examination and by histological examination and culture at the study end 4 weeks after ending all therapy. Results. At the end of the trial H. pylori was eradicated in 21 of 27 per protocol patients (78%; 95% CI 58–91%) and in 21 of 30 patients included in the trial (70%; 95% CI 51–85%). In 15 of 16 per protocol patients with metronidazole‐sensitive strain (94%; 95% CI 70–100%) the infection was cured, but in contrast eradication was accomplished in only one of 3 patients with a metronidazole‐resistant H. pylori strain. Post‐treatment resistance to metronidazole was observed in 6 cases, although 4 of them had had H. pylori strains sensitive to metronidazole at the initial visit. The gastritis had clearly been improved, and the activity of gastritis had completely disappeared 4 weeks after treatment. Seven adverse events were observed in 7 patients, the intensity of which was moderate in 6 cases. Conclusions. This short‐term triple therapy with pantoprazole, amoxicillin and metronidazole provides an effective regimen especially in patients with metronidazole‐sensitive strain.