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Matrix Metalloproteinase‐3 and Nutrition in HD‐Patients with Dialysis‐related Amyloidosis.
Author(s) -
Makoto I,
Tomohito M,
Kuniaki A,
Eishi M
Publication year - 2003
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1046/j.1492-7535.2003.01270.x
Subject(s) - medicine , gastroenterology , hemodialysis , dialysis , amyloidosis , carpal tunnel syndrome , matrix metalloproteinase 3 , matrix metalloproteinase , surgery
Matrix Metalloproteinase‐3 (MMP‐3) has been linked to articular destruction in rheumatic arthritis. In order to examine the clinical disease activity of HD‐related amyloidosis, we measured circulating MMP‐3 of HD patients with post‐operative carpal tunnel syndrome (CTS). Moreover, for evaluation of nutritional status, we measured mid‐arm circumstance (MAC) and the ratio of extra‐cellular fluid (ECF) to total body water (TBW) by a bioimpedence method. 8 patients (5M/3F) with CTS were suffering from arthralgia and emaciation, mean age 58.2(51–72), treated for an average of 23.6 years (14–31). Levels of serum MMP‐3 were determined by enzyme‐linked immunoassays. In other randomized 11 HD patients (7 M/4F), pre‐dialysis levels of MMP‐3 & IL‐6 were measured together for examining the relationship between MMP‐3 and IL‐6. In the amyloidosis group, MMP‐3 showed remarkably high levels of 558 ng/ml (227–1090). MAC and ECF/TBW ratio were 91.9%(83–102) and 0.364 (0.344–0.375), respectively. More than half of patients with arthralgia showed decreased MAC and excessive extra‐cellular fluids. In the randomized group, MMP‐3 and IL‐6 were correlated positively each other (p = 0.0082). Conclusively, patients with the clinical disease activity of HD‐related amyloidosis have high levels of MMP‐3 and protein energy malnutrition. IL‐6 may mediate increase of MMP‐3 and malnutrition.