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Hyperbaric hyperoxia induces a neuromuscular hyperexcitability: assessment of a reduced response in elite oxygen divers
Author(s) -
Jammes Yves,
Arbogast Sandrine,
Faucher Marion,
Montmayeur Alain,
Tagliarini Ferdinand,
Meliet Jean Louis,
Robinet Claude
Publication year - 2003
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1046/j.1475-097x.2003.00486.x
Subject(s) - hyperoxia , medicine , anesthesia , neuromuscular transmission , oxygen , chemistry , organic chemistry , lung
Summary We compared the changes in compound muscle mass action potential (M‐wave) recorded in vastus lateralis in response to hyperbaric hyperoxia (HBO) in nine combat divers who dived daily while breathing 100% O 2 or O 2 ‐enriched mixture (O 2 divers) to those measured in eight recreational divers who dived occasionally using compressed air/21% O 2 (air divers). The O 2 divers completed a 6‐h HBO exposure in which the inspired oxygen pressure (PiO 2 ) varied from 1·15 to 2·7 absolute atmospheres (ATA), PiO 2 being maintained at 1·15 ATA throughout the first 2‐h period, whereas the air divers only completed a 2‐h HBO exposure with PiO 2 constant at 1·15 ATA. Before HBO exposure, there were no intergroup differences between baseline M‐wave characteristics (amplitude and duration), but the conduction time was significantly shorter in O 2 divers compared with air divers. After 90 min of HBO (1·15 ATA) the air divers demonstrated neuromuscular hyperexcitability, as evidenced by an increased M‐wave amplitude (13%, P <0·01 versus baseline), shortened M‐wave duration (5%, P <0·05 versus baseline), and reduced conduction time (5%, P <0·01 versus baseline). In O 2 divers, similar HBO‐induced M‐wave changes were only observed when PiO 2 was greater than 1·50 ATA. We conclude that HBO elicites neuromuscular hyperexcitability, attenuated in elite O 2 divers.