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Simultaneous non‐invasive assessment of arterial stiffness and haemodynamics – a validation study
Author(s) -
Kööbi Tiit,
Kähönen Mika,
Iivainen Tiina,
Turjanmaa Väinö
Publication year - 2003
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1046/j.1475-097x.2003.00465.x
Subject(s) - repeatability , medicine , impedance cardiography , reproducibility , arterial stiffness , pulse wave velocity , pulse wave analysis , stroke volume , hemodynamics , cardiology , ultrasound , bland–altman plot , nuclear medicine , biomedical engineering , blood pressure , limits of agreement , heart rate , mathematics , radiology , statistics
Summary The purpose of the study was to estimate the reliability of whole‐body impedance cardiography (ICG WB )‐derived pulse wave velocity (PWV) and stroke volume index to pulse pressure (SI/PP) measurements. The repeatability and reproducibility of ICG WB parameters were also determined. Agreement between the impedance and Doppler ultrasound‐based PWV measurements was estimated in 25 healthy subjects in two consecutive measurements. Impedance‐derived SI/PP (SI ICG /PP) estimates were compared with simultaneously measured SI/PP based on thermodilution (SI TD /PP) and direct Fick (SI FICK /PP) methods in 30 surgical patients. PWV measured between the aortic arch and popliteal artery using the impedance technique with selective electrode configuration (PWV IS ) agreed well with the Doppler ultrasound method (PWV DOPP ), the bias (PWV DOPP – PWV IS ) and precision (± SD of differences) being 0·00 and 0·79 m s −1 , respectively. PWV derived from the whole‐body and popliteal impedance plethysmograms (PWV ICG ) overestimated slightly PWV DOPP values. The repeatability value for PWV IS was excellent, being 0·54 m s −1 . The reproducibility values for PWV DOPP and PWV IS were very similar (2·17 and 2·42 m s −1 , respectively). Changes in PWV IS correlated strongly with changes in PWV DOPP ( r =0·74; P <0·0001), indicating that both methods reflected the true physiological variation in PWV. The agreement between SI ICG /PP and SI TD /PP or SI FICK was almost identical to the agreement between the SI TD /PP and SI FICK /PP. In conclusion,whole‐body impedance cardiography provides handy and reliable means of evaluating arterial stiffness on the basis of PWV and SI/PP simultaneously with conventional haemodynamic parameters. The method is highly repeatable and reproducible.