Open AccessOxidative stress in Caenorhabditis elegans : protective effects of superoxide dismutase/catalase mimetics
Author(s) -
Sampayo James N.,
Olsen Anders,
Lithgow Gordon J.
Publication year - 2003
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1046/j.1474-9728.2003.00063.x
Subject(s) - superoxide dismutase , paraquat , caenorhabditis elegans , catalase , oxidative stress , biology , reactive oxygen species , biochemistry , pharmacology , gene
Summary The lifespan of Caenorhabditis elegans can be extended by the administration of synthetic superoxide dismutase/catalase mimetics (SCMs) without any effects on development or fertility. Here we demonstrate that the mimetics, Euk‐134 and Euk‐8, confer resistance to the oxidative stress‐inducing agent, paraquat and to thermal stress. The protective effects of the compounds are apparent with treatments either during development or during adulthood and are independent of an insulin/IGF‐I‐like signalling pathway also known to affect thermal and oxidative stress resistance. Worms exposed to the compounds do not induce a cellular stress response and no detrimental effects are observed.