Open AccessIroning out Parkinson's disease: is therapeutic treatment with iron chelators a real possibility?
Author(s) -
Kaur Deepinder,
Andersen Julie K.
Publication year - 2002
Publication title -
aging cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 140
eISSN - 1474-9726
pISSN - 1474-9718
DOI - 10.1046/j.1474-9728.2002.00001.x
Subject(s) - oxidative stress , parkinson's disease , disease , exacerbation , biology , medicine , pharmacology , immunology , endocrinology
Summary Levels of iron are increased in the brains of Parkinson's disease (PD) patients compared to age‐matched controls. This has been postulated to contribute to progression of the disease via several mechanisms including exacerbation of oxidative stress, initiation of inflammatory responses and triggering of Lewy body formation. In this minireview, we examine the putative role of iron in PD and its pharmacological chelation as a prospective therapeutic for the disease.