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Neurodegenerative Disease and Treatments
Author(s) -
KC Suen,
Jacques Hugon,
KF So,
Rcc Chang
Publication year - 2003
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1474-1644.2003.2175_9.x
Subject(s) - citation , disease , medicine , psychology , library science , computer science
The association of apolipoprotein E gene polymorphisms with Alzheimer’s disease and vascular dementia has been reported in several populations including one from a rural community in North India. However, the association of Apo E polymorphism with VaD is yet to be established in this population. Material and methods: In a case–control study involving 54 cases of dementia (AD-29 and VaD-25) and 76 age matched healthy controls blood was analysed for the Apoe polymorphism. Results: The frequency of e4 allele was significantly higher among cases of AD and VaD compared with controls (p < 0.001). The e3e3 (p < 0.05) and e3d3 (p < 0.001) genotypes were found to be protective. The odds of developing AD or VaD were at 4.4 and 3.7 times higher respectively in presence of even a single even e4 allele. Results: Our results suggests that the increased risk of developing AD or VaD is similar among Asian Indians in presence of apo e4 compared with Caucasian population.