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Structure and pharmacology of swelling‐sensitive chloride channels, I Cl,swell
Author(s) -
D'Anglemont De Tassigny Alexandra,
Souktani Rachid,
Ghaleh Bijan,
Henry Patrick,
Berdeaux Alain
Publication year - 2003
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1046/j.1472-8206.2003.00197.x
Subject(s) - chloride channel , swell , swelling , electrophysiology , chloride , chemistry , biophysics , apoptosis , pharmacology , microbiology and biotechnology , neuroscience , biology , medicine , biochemistry , pathology , physics , organic chemistry , thermodynamics
Since several years, the interest for chloride channels and more particularly for the enigmatic swelling‐activated chloride channel (I Cl,swell ) is increasing. Despite its well‐characterized electrophysiological properties, the I Cl,swell structure and pharmacology are not totally elucidated. These channels are involved in a variety of cell functions, such as cardiac rhythm, cell proliferation and differentiation, cell volume regulation and cell death through apoptosis. This review will consider different aspects regarding structure, electrophysiological properties, pharmacology, modulation and functions of these swelling‐activated chloride channels.