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Cough after inhalation of corticosteroids delivered from spacer devices in children with asthma
Author(s) -
Dubus JeanChristophe,
Mély Laurent,
Huiart Laetitia,
Marguet Christophe,
Roux Pascal Le
Publication year - 2003
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1046/j.1472-8206.2003.00191.x
Subject(s) - medicine , fluticasone propionate , inhalation , asthma , budesonide , anesthesia , fluticasone , corticosteroid , inhaler , inhaled corticosteroids , side effect (computer science) , surgery , computer science , programming language
Children using a spacer device rather than another device for delivering inhaled corticosteroids (ICS) has been identified as a risk factor for cough immediately after inhalation. The aim of this study was to point out the different factors influencing the occurrence of such lateral side‐effects. We studied this local side‐effect in 402 asthmatic children (55.6 ± 34.9 months; 65.6% boys) treated for at least 1 month with beclomethasone dipropionate ( n = 331), budesonide ( n = 47) or fluticasone propionate ( n = 24) delivered from pressurized metered‐dose inhalers and small (75.1%) or large volume (24.8%) spacer devices mainly used with face mask (90.7%). A total of 219 patients (54.5%), treated with either high doses of ICS or ICS and long‐acting β 2‐agonist, were considered as having severe asthma. Cough was reported after each inhalation of corticosteroids in 216 patients (53.7%). Among them, about 30% also complained of cough with β 2‐agonists. Despite different propellants and dispersants, all corticosteroids induced cough similarly. Cough was not linked with asthma severity, but was significantly related to therapy duration and use of long‐acting β 2‐agonist. Type and volume of the spacer device, use of a face mask or mouthpiece were not influencing factors. Cough after inhalation of corticosteroids delivered from spacer devices is a frequent local side‐effect in children with asthma. This side effect can greatly alter compliance. A practitioner must be sought at each visit.