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Warming and response to contractile agents in calf cardiac vein: role of the nitric oxide
Author(s) -
Atalık K. E.,
Şahin A. S.,
Ulusoy H. B.,
Doğan N.
Publication year - 2003
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1046/j.1472-8206.2003.00142.x
Subject(s) - carbachol , nitric oxide , medicine , calcium , chemistry , endocrinology , sodium , potassium , vein , sodium nitroprusside , chloride , zoology , biology , organic chemistry , stimulation
Abstract The effects of warming on the response to various contractile agents of calf cardiac vein were studied using 2.5‐mm long cylindrical segments. Concentration–response curves for carbachol (10 −9 –3 × 10 −4 m ), 5‐hydroxytryptamine (5‐HT; 10 −8 –3 × 10 −3 ), potassium chloride (KCl; 10 −4 –5 × 10 −2 m ) and calcium chloride (CaCl 2 ; 10 −4 –10 −2 ) were isometrically recorded at 37 and 41 °C (warming). During warming the sensitivity, but not the maximal response, of carbachol 5‐HT, KCl, and CaCl 2 was significantly higher than at 37 °C. Warming to 41 °C after treatment with N G ‐nitro‐L arginine methyl esther (10 −5 m ) did not modify the effect of warming. These results suggest that nitric oxide seems to have no role in the warming‐induced responses in calf cardiac vein.