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Effect of amitriptyline on gastric ulceration
Author(s) -
Sen T.,
Abdulsalam C. A.,
Pal S.,
Sen S.,
Karmakar S.,
Saravanan K. S.,
Nag Chaudhuri A. K.
Publication year - 2002
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1046/j.1472-8206.2002.00092.x
Subject(s) - amitriptyline , aspirin , drug , gastric content , chemistry , pharmacology , alcohol , stomach , stress ulcer , medicine , biochemistry
Amitriptyline significantly inhibited alcohol, aspirin, indomethacin and cold‐restraint stress‐induced ulceration. Secretory studies conducted in pyloric‐ligated rats revealed that the drug, at the doses employed, significantly reduced total acidity and protein content. However, significant reductions of the gastric volume were only observed at the highest dose of the drug. In another set of experiments, when 50% alcohol (v/v) was administered to the pyloric‐ligated rats pretreated with amitriptyline, it was observed that the drug significantly reduced the pH, total acidity and protein content.