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Isoniazid pharmacokinetics in children according to acetylator phenotype
Author(s) -
Rey Elisabeth,
Gendrel Dominique,
Treluyer Jean Marc,
Tran Agnès,
ParienteKhayat Ann,
D'Athis Philippe,
Pons Gérard
Publication year - 2001
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1046/j.1472-8206.2001.00044.x
Subject(s) - isoniazid , pharmacokinetics , volume of distribution , half life , medicine , plasma clearance , population , oral administration , pharmacology , distribution (mathematics) , oral dose , chemistry , endocrinology , gastroenterology , pathology , tuberculosis , mathematical analysis , mathematics , environmental health
The pharmacokinetics of isoniazid (INH) was studied in children (0–196 months old) according to their acetylator phenotype, estimated from the metabolic acetyl INH/INH molar plasma concentration ratio (MR) measured 3 h after INH oral administration. There were 17 slow (MR < 0.48) and 17 fast acetylators (MR ≥ 0.48). The mean apparent plasma clearance was significantly lower, the mean apparent volume of distribution higher and the half‐life longer in the slow acetylator group (C1, 0.298 ± 0.099 L/h/kg; Vd, 1.56 ± 0.65 L/kg; t1/2, 3.88 ± 01.89 h) than in the fast acetylator group (Cl, 0.528 ± 0.234 L/h/kg; Vd, 1.06 ± 0.45; t1/2, 1.64 ± 1.1 h). The half‐life decreased with age. An impaired isoniazid elimination was suggested in children less than three months old, which may be in favour of an individual dose adjustment in this population.