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Effects of six antihypertensive drugs on blood pressure and hypothalamic GABA content in spontaneously hypertensive rats
Author(s) -
Guan Ying,
Miao ChaoYu,
Su DingFeng
Publication year - 2001
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1046/j.1472-8206.2001.00033.x
Subject(s) - nitrendipine , blood pressure , endocrinology , captopril , medicine , hydrochlorothiazide , bicuculline , hypothalamus , prazosin , gabaa receptor , spontaneously hypertensive rat , pueraria , atenolol , antagonist , pharmacology , chemistry , receptor , alternative medicine , pathology
In order to investigate the effects of antihypertensive drugs on blood pressure and γ‐amino butyric acid (GABA) content in the hypothalamus and the possible relationship between blood pressure decrease and GABA content changes, blood pressure and GABA contents after chronic (20 weeks) treatments of nitrendipine, atenolol, captopril, hydrochlorothiazide, dihydralazine and prazosin were studied in spontaneously‐hypertensive rats (SHR). The acute and subacute (1 week) effects of nitrendipine on GABA contents was also observed in SHR. It was found that 20 week treatments with six different antihypertensive agents produced a decrease in systolic blood pressure and an increase in GABA content. The blood pressure level was significantly correlated with GABA content in the hypothalamus, but not with that in the cortex. Acute treatment with a single dose of nitrendipine, did not alter GABA content. Bicuculline, a GABA receptor antagonist, did not attenuate the hypotensive effect of nitrendipine. In conclusion, chronic treatments by different antihypertensive agents produced an increase of hypothalamic GABA content and a decrease of blood pressure. The increase of GABA content induced by nitrendipine seems likely to be secondary to blood pressure decrease.