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Effect of centrally administered prolactin on gastric and duodenal ulcers in rats
Author(s) -
Asad M.,
Shewade D. G.,
Koumaravelou K.,
Abraham B. K.,
Vasu S.,
Ramaswamy S.
Publication year - 2001
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1046/j.1472-8206.2001.00029.x
Subject(s) - cysteamine , medicine , gastroenterology , ulcer index , pylorus , gastric acid , prolactin , pepsin , acetic acid , endocrinology , stomach , gastric mucosa , chemistry , biochemistry , hormone , enzyme
The effect of centrally administered prolactin on gastric acid secretion and experimentally‐induced gastric and duodenal ulcers was studied. The acute gastric ulcer models used were pylorus ligation, indomethacin‐induced and ethanol‐induced gastric ulcers. Chronic gastric ulcers were induced using acetic acid and duodenal ulcers by cysteamine hydrochloride. In pylorus ligated rats, prolactin (1 μg/kg icv) produced 45% increase in gastric content volume, significant increase in free acidity ( P < 0.001), total acidity ( P < 0.001) and ulcer index ( P < 0.001). It did not show any significant effect on ethanol‐induced and indomethacin‐induced gastric ulcers. Prolactin increased the ulcer index ( P < 0.001) and ulcer score ( P < 0.05) in acetic acid‐induced chronic gastric ulcers. It also increased ulcer area ( P < 0.05) in cysteamine‐induced duodenal ulcers. Therefore, the proulcerogenic activity of prolactin was due to its gastric hypersecretory effect.