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Endoscopic evaluation of the gastrotolerance of short‐term antalgic treatment with low dose k‐diclofenac: a comparison of ibuprofen and aspirin
Author(s) -
Mahé Isabelle,
Mouly Stéphane,
Mahé Emmanuel,
Diemer Myriam,
Knellwolf AnneLaure,
Simoneau Guy,
Caulin Charles,
Bergmann JeanFrançois
Publication year - 2001
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1046/j.1472-8206.2001.00004.x
Subject(s) - ibuprofen , diclofenac , aspirin , medicine , anesthesia , pharmacology
In a short‐term gastro‐duodenal endoscopic study in 12 healthy volunteers, the gastrotoxicity was not different after intake of diclofenac‐K 12.5 mg (0.33) or ibuprofen 200 mg (0.42, P =0.66) but significantly higher after aspirin 500 mg (2.67, P =0.002).