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S15176 and S16950 interaction with Cyclosporin A antiproliferative effect on cultured human lymphocytes[Note 1. The first two authors were equally involved in the ...]
Author(s) -
Albengres Edith,
Le Louët Hervé,
D'Athis Philippe,
Tillement JeanPaul
Publication year - 2001
Publication title -
fundamental and clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 73
eISSN - 1472-8206
pISSN - 0767-3981
DOI - 10.1046/j.1472-8206.2001.00001.x
Subject(s) - nephrotoxicity , toxicity , trimetazidine , pharmacology , chemistry , apoptosis , drug interaction , drug , biology , biochemistry , organic chemistry
S15176 and S16950 are trimetazidine derivatives that antagonize more strongly than the parent drug mitochondrial toxicity, which leads to cellular hypoxia and nephrotoxicity in kidneys experimentally exposed to cyclosporin A. We have investigated whether every derivative might interact or not with the inhibitory effect of Cyclosporin A on the proliferation of cultured human lymphocytes. S15176 significantly increased the antilymphoproliferative effect of Cyclosporin A, whereas S15176 by itself neither displayed any antilymphoproliferative effect, nor did it induce any apoptotic process in cultured human lymphocytes. The effect of S16950 was not significant.