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Bactericidal activity of citrate against Gram‐positive cocci
Author(s) -
Lee Y.L.,
Thrupp L.,
Owens J.,
Cesario T.,
Shanbrom E.
Publication year - 2001
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1046/j.1472-765x.2001.01011.x
Subject(s) - antimicrobial , microbiology and biotechnology , preservative , antibiotics , coagulase , staphylococcus , biology , bacteria , chemistry , staphylococcus aureus , food science , genetics
Aims: Coagulase‐negative staphylococci (CNS) are now important nosocomial pathogens and are usually resistant to multiple antibiotics. Citrate is an alternative antimicrobial product which has been used as a preservative. Methods and Results: In this pilot study the bactericidal activity of Na citrate against 10 isolates of CNS and 6 other gram‐positive pathogens was examined and compared with that of Na lactate. Conclusions: All staphylococci tested were susceptible (≥ 2 log 10 killing) to citrate at 6·25–25 mg ml −1 . Na lactate showed only modest killing at 50 or 100 mg ml −1 . Significance and Impact of the Study: Citrate may warrant broader evaluation as an antimicrobial additive such as in topical agents.