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Frequency of Escherichia coli strains producing the cytotoxic necrotizing factor (CNF1) in nosocomial urinary tract infections
Author(s) -
Landraud L.,
Gauthier M.,
Fosse T.,
Boquet P.
Publication year - 2000
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1046/j.1472-765x.2000.00698.x
Subject(s) - escherichia coli , microbiology and biotechnology , virulence , hemolysin , virulence factor , fimbria , urinary system , biology , cytotoxic t cell , bacteria , gene , genetics , in vitro , endocrinology
The presence of cytotoxic necrotizing factor 1 (CNF1), together with various associated virulence factors (alpha‐haemolysin, P‐, S‐ and A‐fimbriae), was screened in 175 uropathogenic Escherichia coli strains isolated from hospitalized adult patients. The cnf1 gene was detected in 30% of the selected strains independently of the severity of the clinical urinary infection. A significant association between CNF1, haemolytic activity and the products of the pap/sfa genes was found. However, CNF1 appeared not to play a major role in nosocomial E. coli urinary tract infections..