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Antimicrobial activity of Mitracarpus scaber extract and isolated constituents
Author(s) -
Bisignano G.,
Sanogo R.,
Marino A.,
Aquino R.,
‘angelo V. D.,
Germanograve M. P.,
De Pasquale R.,
Pizza C.
Publication year - 2000
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1046/j.1472-765x.2000.00692.x
Subject(s) - antimicrobial , candida albicans , traditional medicine , rutin , kaempferol , staphylococcus aureus , antibacterial activity , gallic acid , minimum inhibitory concentration , broth microdilution , pharmacognosy , chemistry , microbiology and biotechnology , antibacterial agent , biology , biological activity , bacteria , flavonoid , biochemistry , medicine , antioxidant , antibiotics , in vitro , genetics
G. BISIGNANO, R. SANOGO, A. MARINO, R. AQUINO, V. D’ANGELO, M.P. GERMANO★,R. DE PASQUALE & C. PIZZA.2000.The antimicrobial activity of a methanol extract and isolated constituents of Mitracarpus scaber , a species used in folk medicine by West African native people, was evaluated against Staphylococcus aureus and Candida albicans strains. The mitracarpus methanol extract possesses both antibacterial and antimycotic activities (minimum inhibitory concentration—MIC 31·25 and 62·50 μg ml − , respectively). This extract was subsequently fractioned and monitored by bioassays leading to the isolation of seven compounds screened for antibacterial and antimycotic activities. Among these compounds, gallic acid and 3,4,5‐trimethoxybenzoic acid inhibited the growth of Staph. aureus (MIC 3·90 and 0·97 μg ml − ). 4‐Methoxyacetophenone and 3,4,5‐trimethoxyacetophenone effectively inhibited C. albicans (MIC 1·95 μg ml − ). The other compounds (kaempferol‐3‐O‐rutinoside, rutin and psoralen) which were also isolated showed low antibacterial and antimycotic activities (125–500 μg ml − ).